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2025 Publications

Jacques K, Coles BLK, van der Kooy D. Pancreatic stem cells originate during the pancreatic progenitor developmental stage. Front Cell Dev Biol. 2025 Feb 18;13:1521411. doi: 10.3389/fcell.2025.1521411. PMID: 40040790; PMCID: PMC11876382.

2024 Publications

Maal-Bared, G.,  Yee, M.,  Harding, E. K.,  Ghebreselassie, M.,  Bergamini, M.,  Choy, R.,  Kim, E.,  Di Vito, S., Patel, M.,  Amirzadeh, M.,  Grieder, T. E.,  Coles, B. L.,  Nagy, J. I.,  Bonin, R. P.,  Steenland, H. W., &  D.van der Kooy (2024).  Connexin-36-positive gap junctions in ventral tegmental area GABA neurons sustain opiate dependence. European Journal of Neuroscience,  59(12),  3422–3444. https://doi.org/10.1111/ejn.16366
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‍Mokady D, Charish J, Barretto-Burns P, Grisé KN, Coles BLK, Raab S, Ortin-Martinez A, Müller A,Fasching B, Jain P, Drukker M, van der Kooy D, Steger M. (2024). Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model. International Journal of Molecular Sciences. 25(3): 1521-1539.http://dx.doi.org/10.3390/ijms25031521

Vargas-Perez H, Minauro-Sanmiguel F, Ting-A-Kee R, Grieder TE, Méndez-Díaz M, Prospéro-García O, van der Kooy D. Rewarding Effects of the Hallucinogen 4-AcO-DMT Administration and Withdrawal in Rats: A Challenge to the Opponent-Process Theory. Neurosci Lett. 2024 Jan 18;820:137597. doi: 10.1016/j.neulet.2023.137597

 

2023 Publications

Vargas-Perez H, Grieder T, van der Kooy D (van der Kooy’s h-index 104). (2023). Neural plasticity in theventral tegmental area, aversive motivation during drug withdrawal and hallucinogenic therapy. Journal of Psychoactive Drugs. 55(1): 62-72.https://doi.org/10.1080/02791072.2022.2033889

Yammine S, Burns I, Gosio J, Peluso A, Merritt D, Innes B, Coles B, Yan WR, Bader GD, Morshead C, van der Kooy D. (2023). Fate specification of GFAP-negative primitive neural stem cells and their progeny at clonal resolution. Stem Cells and Development.https://doi.org/10.1089/scd.2023.0038

2022 Publications

Merritt DM, MacKay-Clackett I, Almeida SMT, Tran C, Ansar S, van der Kooy D. (2022). Arrestin-mediated Desensitization Enables Olfactory Discrimination in C. elegans. PNAS. 119(31): e2116957119.http://dx.doi.org/doi:10.1073/pnas.2116957119

Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. (2022). Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-nondependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. European Journal of Neuroscience. 55(3): 714-724.https://doi.org/10.1111/ejn.15579

2021 Publications

Grisé KN, Coles BLK, Bautista NX, van der Kooy D. (2021). Activation of adult mammalian retinal stemcells in vivo via antagonism of BMP and sFRP2. Stem Cell Research & Therapy. 12(1): 560. https://doi.org/10.1186/s13287-021-02630-0

Adams K, Neemat M, Green-Holland M, Vonderwalde I, Umebayashi D, Sachewsky N, Coles BLK, vander Kooy D, Morshead CM. (2021). Constraint-induced movement therapy promotes motor recovery afterneonatal stroke in the absence of neural precursor activation. European Journal of Neuroscience. 53(4):1334:1349.http://dx.doi.org/doi.org/10.1111/ejn.14993

Baker AEG, Cui H, Ballios BG, Ing S, Yan P, Wolfer J, Wright T, Dang M, Gan NY, Cooke MJ, Ortín-Martínez A, Wallace VA, van der Kooy D, Devenyi R, Shoichet MS. (2021). Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute. Biomaterials. 271: 120750.https://doi.org/10.1016/j.biomaterials.2021.120750

Baakdhah TW, Coles BL, van der Kooy S. (2021). A defined subset of clonal retinal stem cell spheres isbiased to RPE differentiation. iScience. 24(6): 102574.https://doi.org/10.1016/j.isci.2021.102574

Coles BLK, Labib M, Poudineh M, Innes BT, Belair-Hickey J, Gomis S, Wang Z, Bader GD, SargentEH, Kelley OS, van der Kooy D. (2021). A microfluidic platform enables comprehensive gene expressionprofiling of mouse retinal stem cells. Lab on a Chip. 21(22): 4464-4476.http://dx.doi.org/DOI:10.1039/d1lc00790d

Grisé KN, Bautista NX, Jacques-Smith K, Coles BLK, van der Kooy D. (2021). Glucocorticoid agonistsenhance retinal stem cell self-renewal and proliferation. Stem Cell Research & Therapy. 12(1): 83.http://dx.doi.org/10.1186/s13287-021-02136-9

Ballios BG, Khalili S, Shoichet MS, van der Kooy D. (2019). Induction of Rod and Cone Photoreceptor-Specific Progenitors from Stem Cells. Adv Exp Med Biol. 1185:551-555.https://doi.org/10.1007/978-3-030-27378-1_90

Sachewsky N, Xu W, Fuehrmann T, van der Kooy D, Morshead CM. (2019). Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain. Sci Rep. 9(1):17730.https://doi.org/10.1038/s41598-019-54143-9

Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW. (2019). Cell competition during reprogramming gives rise to dominant clones. Science. 364(6438):eaan0925. https://doi.org/10.1126/science.aan0925

Brokhman I, Xu J, Coles BLK, Razavi R, Engert S, Lickert H, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D. (2019). Dual embryonic origin of the mammalian enteric nervous system. Dev Biol. 445(2):256-270. https://doi.org/10.1016/j.ydbio.2018.11.014

2020 Publications

Yee M, Maal-Bared G, Ting-A-Kee R, Chwalek M, Mackay-Clackett I, Bergamini M, Grieder T, van der Kooy D. (2020). Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versuscore. European Journal of Neuroscience. 52(3): 3074-3086.http://dx.doi.org/doi: 10.1111/ejn.14718

Ahuja AS, Mothe A, Khazaei M, Badhiwala J, Gilbert EA, van der Kooy D, Morshead CM, Tator C, Fehlings M. (2020). The leading edge – emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Translational Medicine. 9: 1509-1530.https://doi.org/10.1002/sctm.19-0135

Mitrousis N, Hacibekiroglu S, Ho M, Sauvé Y, Nagy A, van der Kooy D, Shoichet MS. (2020). Hydrogel mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration. Biomaterials. 257: 120233.http://dx.doi.org/10.1016/j.biomaterials.2020.120233

DeVeale B, van der Kooy D. (2020). Parental bias has benefits. Neuron. 107(6): 1160–1179.http://dx.doi.org//10.1016/j.neuron.2020.08.023

2019 Publications

Wolfe GS, Tong VW, Merritt DM, Stegeman GW, Flibotte S, van der Kooy D. (2019). A receptor tyrosine kinase plays separate roles in sensory integration and associative learning in C. elegans. eNeuro. 6(4): ENEURO.0244-18.2019.http://dx.doi.org/10.1523/ENEURO.0244-18.2019

Grieder TE, Besson M, Maal-Bared G, Pons S, Maskos U, van der Kooy D. (2019). β2* nAChRs onVTA dopamine and GABA neurons separately mediate nicotine aversion and reward. PNAS. 116(51):25968-25973.http://dx.doi.org/10.1073/pnas.1908724116

Merritt D, Melkis JG, Kwok B, Tran C, van der Kooy D. (2019). Analysis of mutants suggests Kaminblocking in C. elegans is due to interference with memory recall rather than storage. Scientific Reports.9(1): 2371.http://dx.doi.org/10.1038/s41598-019-38939-3

Baakdhah T, van der Kooy D. (2019). Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor. Biotechnology Progress. 35(3): e2800.http://dx.doi.org/10.1002/btpr.2800

2018 Publications

Rumajogee P, Altamentova S, Li L, Li J, Wang J, Kuurstra A, Khazaei M, Beldick S, Menon RS, van derKooy D, Fehlings MG. (2018). Exogenous neural precursor cell transplantation results in structural andfunctional recovery in a hypoxic-ischemic hemiplegic mouse model. eNeuro. 5(5): ENEURO.0369-18.2018.http://dx.doi.org/10.1523/ENEURO.0369-18.2018

Li N, van der Kooy D. (2018). Mutations in the guanylate cyclase gcy-28 neuronally dissociate naiveattraction and memory retrieval. European Journal of Neuroscience. 48(11): 3367-3378.http://dx.doi.org/10.1111/ejn.14221

Khalili S, Ballios B, Belair-Hickey J, Donaldson L, Liu J, Coles B, Grisé K, Bader G, Wallace V, Bernier G, Shoichet M, van der Kooy D. (2018). Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells. Stem Cell Research. 33: 215-227.http://dx.doi.org/doi: 10.1016/j.scr.2018.11.005

Gomis S, Labib M, Coles BLK, van der Kooy D, Sargent EH, Kelley SO. (2018). Single-cell tumblingenables high-resolution size profiling of retinal stem cells. ACS Applied Materials & Interfaces. 10:34811-34816. http://dx.doi.org/10.1021/acsami.8b10513

2017 Publications

Grieder TE, Besson M, Maskos U, van der Kooy D. (2017). Deletion of α5 nicotine receptor subunitsabolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptorantagonism. European Journal of Neuroscience. 46(1): 1673-1681.https://doi.org/10.1111/ejn.13605

Coles-Takabe, B., van der Kooy, D. (2017). P-Cadherin is necessary for retinal stem cell behavior in vitro, but not in vivo. Stem Cell Research. 21: 141-147.https://doi.org/10.1016/j.scr.2017.05.001

Reeve RL, Yammine SZ, Morshead CM, van der Kooy D. (2017). Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain. Stem Cells. 35(9):2071-2082. https://doi.org/10.1002/stem.2662

Vargas-Perez H, Grieder TE, Ting-A-Kee R, Maal-Bared G, Chwalek M, van der Kooy D. (2017). A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents. Eur J Neurosci. 45(11):1410-1417. https://doi.org/10.1111/ejn.13572

2016 Publications

Führmann, T., Tam, RY., Ballarin, B., Coles, B., Elliott Donaghue, I., van der Kooy, D., Nagy, A., Tator,CH., Morshead, CM,. Shoichet, MS. (2016). Injectable hydrogel promotes early survival of inducedpluripotent stem cell-derived oligodendrocytes and attenuates long-term teratoma formation in a spinal cord injury model. Biomaterials. 83: 23-36.https://doi.org/10.1016/j.biomaterials.2015.12.032

Huroy S, Kanawaty A, Magomedova L, Cummins CL, George SR, van der Kooy D, Henderson JT. (2016). EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function. Behavioral Brain Research. 308(244): 85-96.https://doi.org/10.1016/j.bbr.2015.09.023

Umebayashi D, Coles B, van der Kooy D. (2016). Enrichment of Oligodendrocyte Progenitors from Differentiated Neural Precursors by Clonal Sphere Preparations. Stem Cells Dev. 25(9):712-28.  https://doi.org/10.1089/scd.2015.0244

‍Reeve RL, Yammine SZ, DeVeale B, van der Kooy D. (2016). Targeted activation of primitive neural stem cells in the mouse brain. Eur J Neurosci. 43(11):1474-85. https://doi.org/10.1111/ejn.1322

Mitrousis N, Tam RY, Baker AEG, van der Kooy D, Shoichet MS. Hyaluronic acid-based hydrogels enable rod photoreceptor survival and maturation in vitro through activation of the mTOR pathway Advanced Functional Materials. 26 (2016) 1975-85. https://doi.org/10.1002/adfm.201504024

2015 Publications

Ballios BG, Cooke MJ, Donaldson L, Coles BL, Morshead CM, van der Kooy D, Shoichet MS. (2015). Ahyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation. Stem Cell Reports. 4(6): 1031-1045.https://doi.org/10.1016/j.stemcr.2015.04.008

Babak T, DeVeale B, Tsang EK, Zhou Y, Li X, Smith KS, Kukurba KR, Zhang R, Li JB, van der Kooy D, Montgomery SB, Fraser HB. (2015). Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse. Nature Genetics. 47(5): 544-549.https://doi.org/10.1038/ng.3274

Razavi R, Najafabadi HS, Abdullah S, Smukler S, Arntfield M, van der Kooy D. (2015). Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production. Diabetes. 4(64): 1311-1323.https://doi.org/10.2337/db14-0070

Ting-A-Kee R, Heinmiller A, van der Kooy D. (2015). A proposed resolution to the paradox of drug reward: Dopamine’s evolution from an aversive signal to a facilitator of drug reward via negative reinforcement. Neurosci Biobehav Rev. 56:50-61. https://doi.org/10.1016/j.neubiorev.2015.06.016

2014 Publications

Sachewsky N, Rose KL, Yu F, Leeder R, Xu W, van der Kooy D, Morshead CM. (2014). Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells. Stem Cell Reports. 2(6): 810-824.https://doi.org/10.1016/j.stemcr.2014.04.008

Greider T, Vargas-Perez H, Herman M, Contet C, Tan L, Freiling J, Clarke L, Crawford E, Koebel P, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. (2014). VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17(12): 1751-1758.https://doi.org/10.1038/nn.3872

Michael IP, Westenskow PD, Hacibekiroglu S, Greenwald AC, Ballios BG, Kurihara T, Li Z, WarrenCM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-ArispeML, Rini JM, van der Kooy D, Friedlander M, Nagy A. (2014). Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO molecular medicine. 6(5): 604-623.https://doi.org/10.1002/emmm.201303708

Vargas-Perez H, Bahi A, Bufalino MR, Ting-A-Kee R, Maal-Bared G, Lam J, Fahmy A, Clarke L, Blanchard JK, Larsen BR, Steffensen S, Dreyer JL, van der Kooy D. (2014). BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions. J Neurosci. 34(23):7899-909.  https://doi.org/10.1523/jneurosci.3776-13.2014

Bufalino MR, van der Kooy D. (2014). The aggregation and inheritance of damaged proteins determines cell fate during mitosis. Cell Cycle. 13(7):1201-7. https://doi.org/10.4161/cc.28106

Teichert AM, Pereira S, Coles B, Chaddah R, Runciman S, Brokhman I, van der Kooy D. (2014). The neural stem cell lineage reveals novel relationships among spermatogonial germ stem cells and other pluripotent stem cells. Stem Cells Dev. 23(7):767-78. https://doi.org/10.1089/scd.2013.0245

Balenci L, van der Kooy D. (2014). Notch signaling induces retinal stem-like properties in perinatal neural retina progenitors and promotes symmetric divisions in adult retinal stem cells. Stem Cells Dev. 23(3):230-44. https://doi.org/10.1089/scd.2013.0177

DeVeale B, Bausch-Fluck D, Seaberg R, Runciman S, Akbarian V, Karpowicz P, Yoon C, Song H, Leeder R, Zandstra PW, Wollscheid B, van der Kooy D. (2014). Surfaceome profiling reveals regulators of neural stem cell function. Stem Cells. 32(1):258-68. https://doi.org/10.1002/stem.1550

2013 Publications

Salewski RP, Buttigieg J, Mitchell RA, van der Kooy D, Nagy A, Fehlings MG. (2013). The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway.Stem Cells and Development. 22(3): 383-396.https://doi.org/10.1089/scd.2012.0218

Pereira S, van der Kooy D. (2013). Entwined engrams: The evolution of associative and non-associative learning. Worm. 2(2):e22725.https://doi.org/10.4161/worm.22725

DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D. (2013). Oct4 is required ~E7.5 for proliferation in the primitive streak. PLoS Genet. 9(11):e1003957. https://doi.org/10.1371/journal.pgen.1003957  

Holowacz T, Alexson TO, Coles BL, Doble BW, Kelly KF, Woodgett JR, Van Der Kooy D. (2013).  The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin. Biol Open. 2(8):812-21. https://doi.org/10.1242/bio.20131941

Balenci L, Wonders C, Coles BL, Clarke L, van der Kooy D. (2013).  Bone morphogenetic proteins and secreted frizzled related protein 2 maintain the quiescence of adult mammalian retinal stem cells. Stem Cells. 31(10):2218-30.https://doi.org/10.1002/stem.1470

Riad-Allen L, van der Kooy D. (2013).  Social defeat stress switches the neural system mediating benzodiazepine conditioned motivation. Behav Neurosci. 127(4):515-23.https://doi.org/10.1037/a0032962

Bufalino MR, DeVeale B, van der Kooy D. (2013).  The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol. 201(4):523-30.https://doi.org/10.1083/jcb.201207052

Ting-A-Kee R, Mercuriano LE, Vargas-Perez H, George SR, van der Kooy D. (2013).  Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner. Behav Brain Res. 247:174-177. https://doi.org/10.1016/j.bbr.2013.03.026

Arntfield M, van der Kooy D. (2013).  The adult mammalian pancreas contains separate precursors of pancreatic and neural crest developmental origins. Stem Cells Dev. 22(15):2145-57. https://doi.org/10.1089/scd.2013.0027

Ting-A-Kee R, Vargas-Perez H, Mabey JK, Shin SI, Steffensen SC, van der Kooy D. (2013). Ventral tegmental area GABA neurons and opiate motivation. Psychopharmacology (Berl). 227(4):697-709. https://doi.org/10.1007/s00213-013-3002-3 ‍
Sellings L, Pereira S, Qian C, Dixon-McDougall T, Nowak C, Zhao B, Tyndale RF, van der Kooy D. (2013). Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. Eur J Neurosci. 37(5):743-56.https://doi.org/10.1111/ejn.12099

Ballios BG, Marigo V, van der Kooy D. Directed differentiation of retinal stem cells into photoreceptors and retinal pigment epithelium. In Kaur N, Vemuri M (Eds.), Neural Stem Cell Assays. Wiley-Blackwell, New Jersey, 2013.http://dx.doi.org/10.1002/9781118308295.ch14

Ting-A-Kee R, Vargas-Perez H, Bufalino MR, Bahi A, Dreyer JL, Tyndale RF, van der Kooy D. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. Euoropean Journal of Neuroscience. 37(6) (2013) 996-1003.https://doi.org/10.1111/ejn.12105

2012 Publications

DeVeale B, van der Kooy D, Babak T. (2012). Critical evaluation of imprinted gene expression by RNASeq: a new perspective. PLoS Genetics. 8: e1002600.https://doi.org/10.1371/journal.pgen.1002600

Pereira S, van der Kooy D. (2012). Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons. J Neurosci. 32(26):9035-44. https://doi.org/10.1523/jneurosci.4221-11.2012

Chaddah R, Arntfield M, Runciman S, Clarke L, van der Kooy D. (2012). Clonal neural stem cells from human embryonic stem cell colonies. J Neurosci. 32(23):7771-81. https://doi.org/10.1523/jneurosci.3286-11.2012

Clarke L, Ballios BG, van der Kooy D. (2012). Generation and clonal isolation of retinal stem cells from human embryonic stem cells. Eur J Neurosci. 36(1):1951-9. https://doi.org/10.1111/j.1460-9568.2012.08123.x

Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. (2012). Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A. 109(8):3101-6.https://doi.org/10.1073/pnas.1114422109

Ballios, B., Clarke, L., Shoichet, M., van der Kooy, D. The adult retinal stem cell is a rare pigmented cell in the ciliary epithelium that can differentiate into photoreceptors. Biology Open (2012) 1:237-246.https://doi.org/10.1242/bio.2012027

2011 Publications

Pacey LK, Doss L, Cifelli C, van der Kooy D, Heximer SP, Hampson DR. (2011). Genetic deletion ofregulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1knockout mouse. Molecular and Cellular Neurosciences. 46(3): 563-572.https://doi.org/10.1016/j.mcn.2010.12.005

Akers KG, Kushner SA, Leslie AT, Clarke L, van der Kooy D, Lerch JP, Frankland PW. (2011). Fetalalcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adultmice. Molecular Brain. 4(29): 1-15.https://doi.org/10.1186/1756-6606-4-29

Wu L, Lam S, Cao H, Guan R, Duan R, van der Kooy D, Bremner R, Molday RS, Hu J. (2011).Subretinal gene delivery using helper-dependent adenoviral vectors. Cell & Bioscience. 1(15): 1-7.https://doi.org/10.1186/2045-3701-1-15

Clarke L, van der Kooy D. (2011). The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells. Stem Cells. 29(9):1448-58. https://doi.org/10.1002/stem.692

Arntfield ME, van der Kooy D. (2011). β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship. Bioessays. 33(8):582-7. https://doi.org/10.1002/bies.201100015

Rowland JW, Lee JJ, Salewski RP, Eftekharpour E, van der Kooy D, Fehlings MG. (2011). Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization. Stem Cells Dev. 20(11):1829-45. https://doi.org/10.1089/scd.2011.0214

Holowacz T, Huelsken J, Dufort D, van der Kooy D. (2011). Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death. Eur J Neurosci. 33(8):1366-75.https://doi.org/10.1111/j.1460-9568.2011.07632.x

Smukler SR, Arntfield ME, Razavi R, Bikopoulos G, Karpowicz P, Seaberg R, Dai F, Lee S, Ahrens R, Fraser PE, Wheeler MB, van der Kooy D. (2011). The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell. 8(3):281-93. https://doi.org/10.1016/j.stem.2011.01.015

2010 Publications

Coles BL, van der Kooy D. (2010). Isolation of retinal stem cells from the mouse eye. J Vis Exp. 43: pii:2209. http://dx.doi.org/10.3791/2209.

Ballios BG, van der Kooy D. (2010). Biology and therapeutic potential of adult retinal stem cells. Can J Ophthalmol. 45(4):342-51. https://doi.org/10.3129/i10-070

Sturgess JE, Ting-A-Kee RA, Podbielski D, Sellings LH, Chen JF, van der Kooy D. (2010). Adenosine A1 and A2A receptors are not upstream of caffeine’s dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects. Eur J Neurosci. 32(1):143-54.https://doi.org/10.1111/j.1460-9568.2010.07247.x

Lin CH, Tomioka M, Pereira S, Sellings L, Iino Y, van der Kooy D. (2010). Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval. J Neurosci. 30(23):8001-11. https://doi.org/10.1523/jneurosci.4636-09.2010

Hoffmann MC, Sellings LH, van der Kooy D. (2010). A diacetyl-induced quiescence in young Caenorhabditis elegans. Behav Brain Res. 214(1):12-7. https://doi.org/10.1016/j.bbr.2010.05.021

Ballios BG, Cooke MJ, van der Kooy D, Shoichet MS. (2010). A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials. 31(9):2555-64. https://doi.org/10.1016/j.biomaterials.2009.12.004

Grieder TE, Sellings LH, Vargas-Perez H, Ting-A-Kee R, Siu EC, Tyndale RF, van der Kooy D. (2010). Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology. 35(4):943-54. https://doi.org/10.1038/npp.2009.198

Inoue T, Coles BL, Dorval K, Bremner R, Bessho Y, Kageyama R, Hino S, Matsuoka M, Craft CM, McInnes RR, Tremblay F, Prusky GT, van der Kooy D. (2010). Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells. 28(3):489-500. https://doi.org/10.1002/stem.279

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2024 Publications

Maal-Bared, G.,  Yee, M.,  Harding, E. K.,  Ghebreselassie, M.,  Bergamini, M.,  Choy, R.,  Kim, E.,  Di Vito, S., Patel, M.,  Amirzadeh, M.,  Grieder, T. E.,  Coles, B. L.,  Nagy, J. I.,  Bonin, R. P.,  Steenland, H. W., &  D.van der Kooy (2024).  Connexin-36-positive gap junctions in ventral tegmental area GABA neurons sustain opiate dependence. European Journal of Neuroscience,  59(12),  3422–3444. https://doi.org/10.1111/ejn.16366
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‍Mokady D, Charish J, Barretto-Burns P, Grisé KN, Coles BLK, Raab S, Ortin-Martinez A, Müller A,Fasching B, Jain P, Drukker M, van der Kooy D, Steger M. (2024). Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model. International Journal of Molecular Sciences. 25(3): 1521-1539.http://dx.doi.org/10.3390/ijms25031521
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Vargas-Perez H, Minauro-Sanmiguel F, Ting-A-Kee R, Grieder TE, Méndez-Díaz M, Prospéro-García O, van der Kooy D. Rewarding Effects of the Hallucinogen 4-AcO-DMT Administration and Withdrawal in Rats: A Challenge to the Opponent-Process Theory. Neurosci Lett. 2024 Jan 18;820:137597. doi: 10.1016/j.neulet.2023.137597

2023 Publications

Vargas-Perez H, Grieder T, van der Kooy D (van der Kooy's h-index 104). (2023). Neural plasticity in theventral tegmental area, aversive motivation during drug withdrawal and hallucinogenic therapy. Journal of Psychoactive Drugs. 55(1): 62-72.https://doi.org/10.1080/02791072.2022.2033889

Yammine S, Burns I, Gosio J, Peluso A, Merritt D, Innes B, Coles B, Yan WR, Bader GD, Morshead C, van der Kooy D. (2023). Fate specification of GFAP-negative primitive neural stem cells and their progeny at clonal resolution. Stem Cells and Development.https://doi.org/10.1089/scd.2023.0038

2022 Publications

Merritt DM, MacKay-Clackett I, Almeida SMT, Tran C, Ansar S, van der Kooy D. (2022). Arrestin-mediated Desensitization Enables Olfactory Discrimination in C. elegans. PNAS. 119(31): e2116957119.http://dx.doi.org/doi:10.1073/pnas.2116957119

Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. (2022). Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-nondependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. European Journal of Neuroscience. 55(3): 714-724.https://doi.org/10.1111/ejn.15579

2021 Publications

Grisé KN, Coles BLK, Bautista NX, van der Kooy D. (2021). Activation of adult mammalian retinal stemcells in vivo via antagonism of BMP and sFRP2. Stem Cell Research & Therapy. 12(1): 560. https://doi.org/10.1186/s13287-021-02630-0

Adams K, Neemat M, Green-Holland M, Vonderwalde I, Umebayashi D, Sachewsky N, Coles BLK, vander Kooy D, Morshead CM. (2021). Constraint-induced movement therapy promotes motor recovery afterneonatal stroke in the absence of neural precursor activation. European Journal of Neuroscience. 53(4):1334:1349.http://dx.doi.org/doi.org/10.1111/ejn.14993

Baker AEG, Cui H, Ballios BG, Ing S, Yan P, Wolfer J, Wright T, Dang M, Gan NY, Cooke MJ, Ortín-Martínez A, Wallace VA, van der Kooy D, Devenyi R, Shoichet MS. (2021). Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute. Biomaterials. 271: 120750.https://doi.org/10.1016/j.biomaterials.2021.120750

Baakdhah TW, Coles BL, van der Kooy S. (2021). A defined subset of clonal retinal stem cell spheres isbiased to RPE differentiation. iScience. 24(6): 102574.https://doi.org/10.1016/j.isci.2021.102574

Coles BLK, Labib M, Poudineh M, Innes BT, Belair-Hickey J, Gomis S, Wang Z, Bader GD, SargentEH, Kelley OS, van der Kooy D. (2021). A microfluidic platform enables comprehensive gene expressionprofiling of mouse retinal stem cells. Lab on a Chip. 21(22): 4464-4476.http://dx.doi.org/DOI:10.1039/d1lc00790d

Grisé KN, Bautista NX, Jacques-Smith K, Coles BLK, van der Kooy D. (2021). Glucocorticoid agonistsenhance retinal stem cell self-renewal and proliferation. Stem Cell Research & Therapy. 12(1): 83.http://dx.doi.org/10.1186/s13287-021-02136-9

Ballios BG, Khalili S, Shoichet MS, van der Kooy D. (2019). Induction of Rod and Cone Photoreceptor-Specific Progenitors from Stem Cells. Adv Exp Med Biol. 1185:551-555.https://doi.org/10.1007/978-3-030-27378-1_90

Sachewsky N, Xu W, Fuehrmann T, van der Kooy D, Morshead CM. (2019). Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain. Sci Rep. 9(1):17730.https://doi.org/10.1038/s41598-019-54143-9

Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW. (2019). Cell competition during reprogramming gives rise to dominant clones. Science. 364(6438):eaan0925. https://doi.org/10.1126/science.aan0925

Brokhman I, Xu J, Coles BLK, Razavi R, Engert S, Lickert H, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D. (2019). Dual embryonic origin of the mammalian enteric nervous system. Dev Biol. 445(2):256-270. https://doi.org/10.1016/j.ydbio.2018.11.014

2020 Publications

Yee M, Maal-Bared G, Ting-A-Kee R, Chwalek M, Mackay-Clackett I, Bergamini M, Grieder T, van der Kooy D. (2020). Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versuscore. European Journal of Neuroscience. 52(3): 3074-3086.http://dx.doi.org/doi: 10.1111/ejn.14718

Ahuja AS, Mothe A, Khazaei M, Badhiwala J, Gilbert EA, van der Kooy D, Morshead CM, Tator C, Fehlings M. (2020). The leading edge - emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Translational Medicine. 9: 1509-1530.https://doi.org/10.1002/sctm.19-0135

Mitrousis N, Hacibekiroglu S, Ho M, Sauvé Y, Nagy A, van der Kooy D, Shoichet MS. (2020). Hydrogel mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration. Biomaterials. 257: 120233.http://dx.doi.org/10.1016/j.biomaterials.2020.120233

DeVeale B, van der Kooy D. (2020). Parental bias has benefits. Neuron. 107(6): 1160–1179.http://dx.doi.org//10.1016/j.neuron.2020.08.023

2019 Publications

Wolfe GS, Tong VW, Merritt DM, Stegeman GW, Flibotte S, van der Kooy D. (2019). A receptor tyrosine kinase plays separate roles in sensory integration and associative learning in C. elegans. eNeuro. 6(4): ENEURO.0244-18.2019.http://dx.doi.org/10.1523/ENEURO.0244-18.2019

Grieder TE, Besson M, Maal-Bared G, Pons S, Maskos U, van der Kooy D. (2019). β2* nAChRs onVTA dopamine and GABA neurons separately mediate nicotine aversion and reward. PNAS. 116(51):25968-25973.http://dx.doi.org/10.1073/pnas.1908724116

Merritt D, Melkis JG, Kwok B, Tran C, van der Kooy D. (2019). Analysis of mutants suggests Kaminblocking in C. elegans is due to interference with memory recall rather than storage. Scientific Reports.9(1): 2371.http://dx.doi.org/10.1038/s41598-019-38939-3

Baakdhah T, van der Kooy D. (2019). Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor. Biotechnology Progress. 35(3): e2800.http://dx.doi.org/10.1002/btpr.2800

2018 Publications

Rumajogee P, Altamentova S, Li L, Li J, Wang J, Kuurstra A, Khazaei M, Beldick S, Menon RS, van derKooy D, Fehlings MG. (2018). Exogenous neural precursor cell transplantation results in structural andfunctional recovery in a hypoxic-ischemic hemiplegic mouse model. eNeuro. 5(5): ENEURO.0369-18.2018.http://dx.doi.org/10.1523/ENEURO.0369-18.2018

Li N, van der Kooy D. (2018). Mutations in the guanylate cyclase gcy-28 neuronally dissociate naiveattraction and memory retrieval. European Journal of Neuroscience. 48(11): 3367-3378.http://dx.doi.org/10.1111/ejn.14221

Khalili S, Ballios B, Belair-Hickey J, Donaldson L, Liu J, Coles B, Grisé K, Bader G, Wallace V, Bernier G, Shoichet M, van der Kooy D. (2018). Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells. Stem Cell Research. 33: 215-227.http://dx.doi.org/doi: 10.1016/j.scr.2018.11.005

Gomis S, Labib M, Coles BLK, van der Kooy D, Sargent EH, Kelley SO. (2018). Single-cell tumblingenables high-resolution size profiling of retinal stem cells. ACS Applied Materials & Interfaces. 10:34811-34816. http://dx.doi.org/10.1021/acsami.8b10513

2017 Publications

Grieder TE, Besson M, Maskos U, van der Kooy D. (2017). Deletion of α5 nicotine receptor subunitsabolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptorantagonism. European Journal of Neuroscience. 46(1): 1673-1681.https://doi.org/10.1111/ejn.13605

Coles-Takabe, B., van der Kooy, D. (2017). P-Cadherin is necessary for retinal stem cell behavior in vitro, but not in vivo. Stem Cell Research. 21: 141-147.https://doi.org/10.1016/j.scr.2017.05.001

Reeve RL, Yammine SZ, Morshead CM, van der Kooy D. (2017). Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain. Stem Cells. 35(9):2071-2082. https://doi.org/10.1002/stem.2662
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Vargas-Perez H, Grieder TE, Ting-A-Kee R, Maal-Bared G, Chwalek M, van der Kooy D. (2017). A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents. Eur J Neurosci. 45(11):1410-1417. https://doi.org/10.1111/ejn.13572

2016 Publications

Führmann, T., Tam, RY., Ballarin, B., Coles, B., Elliott Donaghue, I., van der Kooy, D., Nagy, A., Tator,CH., Morshead, CM,. Shoichet, MS. (2016). Injectable hydrogel promotes early survival of inducedpluripotent stem cell-derived oligodendrocytes and attenuates long-term teratoma formation in a spinal cord injury model. Biomaterials. 83: 23-36.https://doi.org/10.1016/j.biomaterials.2015.12.032

Huroy S, Kanawaty A, Magomedova L, Cummins CL, George SR, van der Kooy D, Henderson JT. (2016). EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function. Behavioral Brain Research. 308(244): 85-96.https://doi.org/10.1016/j.bbr.2015.09.023

Umebayashi D, Coles B, van der Kooy D. (2016). Enrichment of Oligodendrocyte Progenitors from Differentiated Neural Precursors by Clonal Sphere Preparations. Stem Cells Dev. 25(9):712-28.  https://doi.org/10.1089/scd.2015.0244

‍Reeve RL, Yammine SZ, DeVeale B, van der Kooy D. (2016). Targeted activation of primitive neural stem cells in the mouse brain. Eur J Neurosci. 43(11):1474-85. https://doi.org/10.1111/ejn.1322

Mitrousis N, Tam RY, Baker AEG, van der Kooy D, Shoichet MS. Hyaluronic acid-based hydrogels enable rod photoreceptor survival and maturation in vitro through activation of the mTOR pathway Advanced Functional Materials. 26 (2016) 1975-85. https://doi.org/10.1002/adfm.201504024

2015 Publications

Ballios BG, Cooke MJ, Donaldson L, Coles BL, Morshead CM, van der Kooy D, Shoichet MS. (2015). Ahyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation. Stem Cell Reports. 4(6): 1031-1045.https://doi.org/10.1016/j.stemcr.2015.04.008

Babak T, DeVeale B, Tsang EK, Zhou Y, Li X, Smith KS, Kukurba KR, Zhang R, Li JB, van der Kooy D, Montgomery SB, Fraser HB. (2015). Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse. Nature Genetics. 47(5): 544-549.https://doi.org/10.1038/ng.3274

Razavi R, Najafabadi HS, Abdullah S, Smukler S, Arntfield M, van der Kooy D. (2015). Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production. Diabetes. 4(64): 1311-1323.https://doi.org/10.2337/db14-0070

Ting-A-Kee R, Heinmiller A, van der Kooy D. (2015). A proposed resolution to the paradox of drug reward: Dopamine's evolution from an aversive signal to a facilitator of drug reward via negative reinforcement. Neurosci Biobehav Rev. 56:50-61. https://doi.org/10.1016/j.neubiorev.2015.06.016

2014 Publications

Sachewsky N, Rose KL, Yu F, Leeder R, Xu W, van der Kooy D, Morshead CM. (2014). Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells. Stem Cell Reports. 2(6): 810-824.https://doi.org/10.1016/j.stemcr.2014.04.008

Greider T, Vargas-Perez H, Herman M, Contet C, Tan L, Freiling J, Clarke L, Crawford E, Koebel P, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. (2014). VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17(12): 1751-1758.https://doi.org/10.1038/nn.3872

Michael IP, Westenskow PD, Hacibekiroglu S, Greenwald AC, Ballios BG, Kurihara T, Li Z, WarrenCM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-ArispeML, Rini JM, van der Kooy D, Friedlander M, Nagy A. (2014). Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO molecular medicine. 6(5): 604-623.https://doi.org/10.1002/emmm.201303708

Vargas-Perez H, Bahi A, Bufalino MR, Ting-A-Kee R, Maal-Bared G, Lam J, Fahmy A, Clarke L, Blanchard JK, Larsen BR, Steffensen S, Dreyer JL, van der Kooy D. (2014). BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions. J Neurosci. 34(23):7899-909.  https://doi.org/10.1523/jneurosci.3776-13.2014

Bufalino MR, van der Kooy D. (2014). The aggregation and inheritance of damaged proteins determines cell fate during mitosis. Cell Cycle. 13(7):1201-7. https://doi.org/10.4161/cc.28106

Teichert AM, Pereira S, Coles B, Chaddah R, Runciman S, Brokhman I, van der Kooy D. (2014). The neural stem cell lineage reveals novel relationships among spermatogonial germ stem cells and other pluripotent stem cells. Stem Cells Dev. 23(7):767-78. https://doi.org/10.1089/scd.2013.0245

Balenci L, van der Kooy D. (2014). Notch signaling induces retinal stem-like properties in perinatal neural retina progenitors and promotes symmetric divisions in adult retinal stem cells. Stem Cells Dev. 23(3):230-44. https://doi.org/10.1089/scd.2013.0177

DeVeale B, Bausch-Fluck D, Seaberg R, Runciman S, Akbarian V, Karpowicz P, Yoon C, Song H, Leeder R, Zandstra PW, Wollscheid B, van der Kooy D. (2014). Surfaceome profiling reveals regulators of neural stem cell function. Stem Cells. 32(1):258-68. https://doi.org/10.1002/stem.1550

2013 Publications

Salewski RP, Buttigieg J, Mitchell RA, van der Kooy D, Nagy A, Fehlings MG. (2013). The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway.Stem Cells and Development. 22(3): 383-396.https://doi.org/10.1089/scd.2012.0218

Pereira S, van der Kooy D. (2013). Entwined engrams: The evolution of associative and non-associative learning. Worm. 2(2):e22725.https://doi.org/10.4161/worm.22725

DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D. (2013). Oct4 is required ~E7.5 for proliferation in the primitive streak. PLoS Genet. 9(11):e1003957. https://doi.org/10.1371/journal.pgen.1003957  

Holowacz T, Alexson TO, Coles BL, Doble BW, Kelly KF, Woodgett JR, Van Der Kooy D. (2013).  The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin. Biol Open. 2(8):812-21. https://doi.org/10.1242/bio.20131941

Balenci L, Wonders C, Coles BL, Clarke L, van der Kooy D. (2013).  Bone morphogenetic proteins and secreted frizzled related protein 2 maintain the quiescence of adult mammalian retinal stem cells. Stem Cells. 31(10):2218-30.https://doi.org/10.1002/stem.1470

Riad-Allen L, van der Kooy D. (2013).  Social defeat stress switches the neural system mediating benzodiazepine conditioned motivation. Behav Neurosci. 127(4):515-23.https://doi.org/10.1037/a0032962

Bufalino MR, DeVeale B, van der Kooy D. (2013).  The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol. 201(4):523-30.https://doi.org/10.1083/jcb.201207052

Ting-A-Kee R, Mercuriano LE, Vargas-Perez H, George SR, van der Kooy D. (2013).  Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner. Behav Brain Res. 247:174-177. https://doi.org/10.1016/j.bbr.2013.03.026

Arntfield M, van der Kooy D. (2013).  The adult mammalian pancreas contains separate precursors of pancreatic and neural crest developmental origins. Stem Cells Dev. 22(15):2145-57. https://doi.org/10.1089/scd.2013.0027

Ting-A-Kee R, Vargas-Perez H, Mabey JK, Shin SI, Steffensen SC, van der Kooy D. (2013). Ventral tegmental area GABA neurons and opiate motivation. Psychopharmacology (Berl). 227(4):697-709. https://doi.org/10.1007/s00213-013-3002-3 ‍
Sellings L, Pereira S, Qian C, Dixon-McDougall T, Nowak C, Zhao B, Tyndale RF, van der Kooy D. (2013). Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. Eur J Neurosci. 37(5):743-56.https://doi.org/10.1111/ejn.12099

Ballios BG, Marigo V, van der Kooy D. Directed differentiation of retinal stem cells into photoreceptors and retinal pigment epithelium. In Kaur N, Vemuri M (Eds.), Neural Stem Cell Assays. Wiley-Blackwell, New Jersey, 2013.http://dx.doi.org/10.1002/9781118308295.ch14
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Ting-A-Kee R, Vargas-Perez H, Bufalino MR, Bahi A, Dreyer JL, Tyndale RF, van der Kooy D. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. Euoropean Journal of Neuroscience. 37(6) (2013) 996-1003.https://doi.org/10.1111/ejn.12105

2012 Publications

DeVeale B, van der Kooy D, Babak T. (2012). Critical evaluation of imprinted gene expression by RNASeq: a new perspective. PLoS Genetics. 8: e1002600.https://doi.org/10.1371/journal.pgen.1002600

Pereira S, van der Kooy D. (2012). Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons. J Neurosci. 32(26):9035-44. https://doi.org/10.1523/jneurosci.4221-11.2012

Chaddah R, Arntfield M, Runciman S, Clarke L, van der Kooy D. (2012). Clonal neural stem cells from human embryonic stem cell colonies. J Neurosci. 32(23):7771-81. https://doi.org/10.1523/jneurosci.3286-11.2012

Clarke L, Ballios BG, van der Kooy D. (2012). Generation and clonal isolation of retinal stem cells from human embryonic stem cells. Eur J Neurosci. 36(1):1951-9. https://doi.org/10.1111/j.1460-9568.2012.08123.x

Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. (2012). Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A. 109(8):3101-6.https://doi.org/10.1073/pnas.1114422109

Ballios, B., Clarke, L., Shoichet, M., van der Kooy, D. The adult retinal stem cell is a rare pigmented cell in the ciliary epithelium that can differentiate into photoreceptors. Biology Open (2012) 1:237-246.https://doi.org/10.1242/bio.2012027

2011 Publications

Pacey LK, Doss L, Cifelli C, van der Kooy D, Heximer SP, Hampson DR. (2011). Genetic deletion ofregulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1knockout mouse. Molecular and Cellular Neurosciences. 46(3): 563-572.https://doi.org/10.1016/j.mcn.2010.12.005

Akers KG, Kushner SA, Leslie AT, Clarke L, van der Kooy D, Lerch JP, Frankland PW. (2011). Fetalalcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adultmice. Molecular Brain. 4(29): 1-15.https://doi.org/10.1186/1756-6606-4-29

Wu L, Lam S, Cao H, Guan R, Duan R, van der Kooy D, Bremner R, Molday RS, Hu J. (2011).Subretinal gene delivery using helper-dependent adenoviral vectors. Cell & Bioscience. 1(15): 1-7.https://doi.org/10.1186/2045-3701-1-15

Clarke L, van der Kooy D. (2011). The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells. Stem Cells. 29(9):1448-58. https://doi.org/10.1002/stem.692

Arntfield ME, van der Kooy D. (2011). β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship. Bioessays. 33(8):582-7. https://doi.org/10.1002/bies.201100015

Rowland JW, Lee JJ, Salewski RP, Eftekharpour E, van der Kooy D, Fehlings MG. (2011). Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization. Stem Cells Dev. 20(11):1829-45. https://doi.org/10.1089/scd.2011.0214

Holowacz T, Huelsken J, Dufort D, van der Kooy D. (2011). Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death. Eur J Neurosci. 33(8):1366-75.https://doi.org/10.1111/j.1460-9568.2011.07632.x

Smukler SR, Arntfield ME, Razavi R, Bikopoulos G, Karpowicz P, Seaberg R, Dai F, Lee S, Ahrens R, Fraser PE, Wheeler MB, van der Kooy D. (2011). The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell. 8(3):281-93. https://doi.org/10.1016/j.stem.2011.01.015

2010 Publications

Coles BL, van der Kooy D. (2010). Isolation of retinal stem cells from the mouse eye. J Vis Exp. 43: pii:2209. http://dx.doi.org/10.3791/2209.

Ballios BG, van der Kooy D. (2010). Biology and therapeutic potential of adult retinal stem cells. Can J Ophthalmol. 45(4):342-51. https://doi.org/10.3129/i10-070

Sturgess JE, Ting-A-Kee RA, Podbielski D, Sellings LH, Chen JF, van der Kooy D. (2010). Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects. Eur J Neurosci. 32(1):143-54.https://doi.org/10.1111/j.1460-9568.2010.07247.x

Lin CH, Tomioka M, Pereira S, Sellings L, Iino Y, van der Kooy D. (2010). Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval. J Neurosci. 30(23):8001-11. https://doi.org/10.1523/jneurosci.4636-09.2010

Hoffmann MC, Sellings LH, van der Kooy D. (2010). A diacetyl-induced quiescence in young Caenorhabditis elegans. Behav Brain Res. 214(1):12-7. https://doi.org/10.1016/j.bbr.2010.05.021

Ballios BG, Cooke MJ, van der Kooy D, Shoichet MS. (2010). A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials. 31(9):2555-64. https://doi.org/10.1016/j.biomaterials.2009.12.004

Grieder TE, Sellings LH, Vargas-Perez H, Ting-A-Kee R, Siu EC, Tyndale RF, van der Kooy D. (2010). Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology. 35(4):943-54. https://doi.org/10.1038/npp.2009.198

Inoue T, Coles BL, Dorval K, Bremner R, Bessho Y, Kageyama R, Hino S, Matsuoka M, Craft CM, McInnes RR, Tremblay F, Prusky GT, van der Kooy D. (2010). Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells. 28(3):489-500. https://doi.org/10.1002/stem.279

For Earlier Publications: Click Here